Voltage-gated sodium channels confer excitability to human odontoblasts: possible role in tooth pain transmission.

@article{Allard2006VoltagegatedSC,
  title={Voltage-gated sodium channels confer excitability to human odontoblasts: possible role in tooth pain transmission.},
  author={Bruno Allard and Henry Magloire and Marie Lise Couble and Jean Christophe Maurin and Françoise Bleicher},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 39},
  pages={29002-10}
}
Odontoblasts are responsible for the dentin formation. They are suspected to play a role in tooth pain transmission as sensor cells because of their close relationship with nerve, but this role has never been evidenced. We demonstrate here that human odontoblasts in vitro produce voltage-gated tetrodotoxin-sensitive Na(+) currents in response to depolarization under voltage clamp conditions and are able to generate action potentials. Odontoblasts express neuronal isoforms of alpha2 and beta2… CONTINUE READING

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