Voltage gated sodium channels as drug discovery targets.

@article{Bagal2015VoltageGS,
  title={Voltage gated sodium channels as drug discovery targets.},
  author={Sharan K. Bagal and Brian E. Marron and Robert M. Owen and R. Ian Storer and Nigel A Swain},
  journal={Channels},
  year={2015},
  volume={9 6},
  pages={360-6}
}
Voltage-gated sodium (NaV) channels are a family of transmembrane ion channel proteins. They function by forming a gated, water-filled pore to help establish and control cell membrane potential via control of the flow of ions between the intracellular and the extracellular environments. Blockade of NaVs has been successfully accomplished in the clinic to enable control of pathological firing patterns that occur in a diverse range of conditions such as chronic pain, epilepsy, and cardiac… CONTINUE READING