Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.

@article{Lock1994VoltagegatedPC,
  title={Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.},
  author={Linette Lock and Debra J. Gilbert and Valerie A. Street and Mary Bascom Migeon and Nancy A. Jenkins and Neal G. Copeland and Bruce L. Tempel},
  journal={Genomics},
  year={1994},
  volume={20 3},
  pages={
          354-62
        }
}
Cloning of the Drosophila Shaker gene established that a neurological phenotype including locomotor dysfunction can be caused by a mutation in a voltage-gated potassium (K) channel gene. Shaker sequences have been used to isolate a large family of related K channel genes from both flies and mammals. Toward elucidating the evolutionary relationship between loci and the potential causal connection that K channels may have to mammalian genetic disorders, we report here the genetic mapping of 12-16… CONTINUE READING
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