Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role.

@article{Kobrinsky2003VoltagegatedMO,
  title={Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role.},
  author={Evgeny Kobrinsky and Elena I Schwartz and Darrell R. Abernethy and Nikolai M. Soldatov},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 7},
  pages={5021-8}
}
Transient increase in intracellular free Ca(2+) concentration generated by the voltage-gated Ca(v)1.2 channels acts as an important intracellular signal. By using fluorescence resonance energy transfer combined with patch clamp in living cells, we present evidence for voltage-gated mobility of the cytoplasmic tails of the Ca(v)1.2 channel and for its regulatory role in intracellular signaling. Anchoring of the C-terminal tail to the plasma membrane caused an inhibition of its state-dependent… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…