Voltage-gated calcium channels in the human adrenal and primary aldosteronism

@article{Felizola2014VoltagegatedCC,
  title={Voltage-gated calcium channels in the human adrenal and primary aldosteronism},
  author={Saulo Jos{\'e} Alves Felizola and Takashi Maekawa and Yasuhiro Nakamura and Fumitoshi Satoh and Yoshikiyo Ono and Kumi Kikuchi and Shizuka Aritomi and Keiichi Ikeda and Michihiro Yoshimura and Katsuyoshi Tojo and Hironobu Sasano},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2014},
  volume={144},
  pages={410-416}
}
Calcium channel blockers can efficiently be used in the treatment of primary aldosteronism (PA) related hypertension, but details on the localization of calcium channel (CC) in the human adrenal and its disorders, including PA, have remained unclear. Therefore, in this study we analyzed the known α subunits of L-, N- and T-type CCs in 74 adrenocortical aldosterone-producing adenomas (APA) and 16 cortisol-producing adenomas (CPA) using quantitative RT-PCR (qPCR). We also examined the status of L… Expand
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References

SHOWING 1-10 OF 27 REFERENCES
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
TLDR
PCP4 immunoreactivity was predominantly detected in APA and in the zona glomerulosa of NA and IHA and indicates that PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells. Expand
Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis
TLDR
The analysis of quantitative reverse transcription-PCR, western blotting, and immunocytological staining indicated the possible presence of N-type calcium channels in human adrenocortical cells (H295R cell line), and the inhibitory activities of some types of dihydropyridine calcium channel blockers showed a dose-dependent inhibition effect on Ang II-induced aldosterone and cortisol production. Expand
Metallothionein-3 (MT-3) in the Human Adrenal Cortex and its Disorders
TLDR
The presence of MT-3 in the ZG of NA, IHA, and AAG, as well as APA may imply a role in the pathophysiology of aldosterone-producing tissues. Expand
Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway
TLDR
GRM3 is considered to regulate steroidogenesis in adrenocortical tissues and when added to angiotensin-II/forskolin treatments, LY354740 decreased aldosterone and cortisol production in H295R cells. Expand
Ca2+ channels and aldosterone secretion: modulation by K+ and atrial natriuretic peptide.
TLDR
It is demonstrated that atrial natriuretic peptide (ANP), an antagonist of aldosterone secretion, alters only the voltage dependence of inactivation of the T-type channel while enhancing the voltage dependent of activation of a subpopulation of L-type channels. Expand
Minireview: aldosterone biosynthesis: electrically gated for our protection.
Aldosterone produced by adrenal zona glomerulosa (ZG) cells plays an important role in maintaining salt/water balance and, hence, blood pressure homeostasis. However, when dysregulated, aldosteroneExpand
Comparison of the Effects of Efonidipine and Amlodipine on Aldosterone in Patients with Hypertension
To prevent cardiovascular disease, targeting aldosterone synthesis and release may be clinically important. Aldosterone production in the adrenal gland is mediated mainly by the T-type calciumExpand
Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R.
TLDR
Results indicate that inhibition of T-type Ca2+ channels is responsible for inhibition of aldosterone production in NCI-H295R cells, indicating additional benefits of this drug for treating renal and cardiovascular diseases, beyond its primary anti-hypertensive effects from blocking L-type calcium channel channels. Expand
Inhibitory action of mibefradil on calcium signaling and aldosterone synthesis in bovine adrenal glomerulosa cells.
TLDR
Mibefradil is highly effective in adrenal glomerulosa cells in reducing T type channel activity and aldosterone biosynthesis, two actions that should contribute to the beneficial effect of the drug in the treatment of hypertension. Expand
Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma
TLDR
Investigation of the prevalence of somatic mutations in aldosterone-producing adenomas in unselected patients with APA found that young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options. Expand
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