Voltage-gated calcium channels in the human adrenal and primary aldosteronism

  title={Voltage-gated calcium channels in the human adrenal and primary aldosteronism},
  author={Saulo J. A. Felizola and T. Maekawa and Y. Nakamura and F. Satoh and H. Sasano},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • Saulo J. A. Felizola, T. Maekawa, +2 authors H. Sasano
  • Published 2014
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Calcium channel blockers can efficiently be used in the treatment of primary aldosteronism (PA) related hypertension, but details on the localization of calcium channel (CC) in the human adrenal and its disorders, including PA, have remained unclear. Therefore, in this study we analyzed the known α subunits of L-, N- and T-type CCs in 74 adrenocortical aldosterone-producing adenomas (APA) and 16 cortisol-producing adenomas (CPA) using quantitative RT-PCR (qPCR). We also examined the status of L… CONTINUE READING
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