Voltage-gated calcium channels and idiopathic generalized epilepsies.

@article{Khosravani2006VoltagegatedCC,
  title={Voltage-gated calcium channels and idiopathic generalized epilepsies.},
  author={Houman Khosravani and Gerald W. Zamponi},
  journal={Physiological reviews},
  year={2006},
  volume={86 3},
  pages={
          941-66
        }
}
The idiopathic generalized epilepsies encompass a class of epileptic seizure types that exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have implicated defects in certain types of voltage-gated calcium channels and their ancillary subunits as important players in this form of epilepsy. Both T-type and P/Q-type channels appear to mediate important contributions to seizure genesis, modulation of network activity, and genetic seizure susceptibility. Here, we… CONTINUE READING

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