Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development.

@article{Chabbert2003VoltagegatedNC,
  title={Voltage-gated Na+ channel activation induces both action potentials in utricular hair cells and brain-derived neurotrophic factor release in the rat utricle during a restricted period of development.},
  author={Christian Chabbert and Ilana M{\'e}chaly and Victor Sieso and Pierre Giraud and Aurore Brugeaud and Jacques Lehouelleur and François Couraud and Jean Valmier and Alain Sans},
  journal={The Journal of physiology},
  year={2003},
  volume={553 Pt 1},
  pages={113-23}
}
The mammalian utricular sensory receptors are commonly believed to be non-spiking cells with electrical activity limited to graded membrane potential changes. Here we provide evidence that during the first post-natal week, the sensory hair cells of the rat utricle express a tetrodotoxin (TTX)-sensitive voltage-gated Na+ current that displays most of the biophysical and pharmacological characteristics of neuronal Na+ current. Single-cell RT-PCR reveals that several alpha-subunit isoforms of the… CONTINUE READING
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