Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion.

@article{House2010VoltagegatedNC,
  title={Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion.},
  author={Carrie House and Charles J. Vaske and Arnold M. Schwartz and Vincent J Obias and Bryan Frank and Truong Luu and Narine A Sarvazyan and Rosalyn Irby and Robert Strausberg and Tim G Hales and Joshua M. Stuart and Norman H. Lee},
  journal={Cancer research},
  year={2010},
  volume={70 17},
  pages={6957-67}
}
Voltage-gated Na(+) channels (VGSC) have been implicated in the metastatic potential of human breast, prostate, and lung cancer cells. Specifically, the SCN5A gene encoding the VGSC isotype Na(v)1.5 has been defined as a key driver of human cancer cell invasion. In this study, we examined the expression and function of VGSCs in a panel of colon cancer cell lines by electrophysiologic recordings. Na(+) channel activity and invasive potential were inhibited pharmacologically by tetrodotoxin or… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

Discovery d scoring of protein interaction subnetworks discriminative of late ge human colon cancer

  • P dreu, S Colnot, C Godard
  • Mol Cell Proteomics
  • 2009

Regulation of po - some formation in macrophages by a splice variant of the sodium nnel SCN 8 A

  • RL lek, RB Irby, QM Guo
  • J Biol Chem
  • 2009

Sc ace ure wor sio ront he i erm an fr eac pa t hoc Tukey)

  • House
  • Nat Rev 2009;9:195–205
  • 2009

Activation G α i 3 triggers cell migration via regulation of GIV

  • RL berts, GR Fink
  • J Cell Biol
  • 2008

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