Voltage-gated K+ channel dysfunction in myocytes from a dog model of subarachnoid hemorrhage.

@article{Jahromi2008VoltagegatedKC,
  title={Voltage-gated K+ channel dysfunction in myocytes from a dog model of subarachnoid hemorrhage.},
  author={B S Jahromi and Yasuo Aihara and Jinglu Ai and Z. D. Zhang and Elena Nikitina and Robert L Macdonald},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2008},
  volume={28 4},
  pages={797-811}
}
Delayed cerebral vasospasm after subarachnoid hemorrhage is primarily due to sustained contraction of arterial smooth muscle cells. Its pathogenesis remains unclear. The degree of arterial constriction is regulated by membrane potential that in turn is determined predominately by K+ conductance (GK). Here, we identified the main voltage-gated K+ (Kv) channels contributing to outward delayed rectifier currents in dog basilar artery smooth muscle as Kv2 class through a combination of… CONTINUE READING

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