Voltage-driven Ca(2+) binding at the L-type Ca(2+) channel triggers cardiac excitation-contraction coupling prior to Ca(2+) influx.


The activation of the ryanodine Ca(2+) release channels (RyR2) by the entry of Ca(2+) through the L-type Ca(2+) channels (Cav1.2) is believed to be the primary mechanism of excitation-contraction (EC) coupling in cardiac cells. This proposed mechanism of Ca(2+)-induced Ca(2+) release (CICR) cannot fully account for the lack of a termination signal for this… (More)
DOI: 10.1021/bi301124a


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