Voltage-dependent sodium channel function is regulated through membrane mechanics.

Abstract

Cut-open recordings from Xenopus oocytes expressing either nerve (PN1) or skeletal muscle (SkM1) Na(+) channel alpha subunits revealed slow inactivation onset and recovery kinetics of inward current. In contrast, recordings using the macropatch configuration resulted in an immediate negative shift in the voltage-dependence of inactivation and activation, as… (More)

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@article{Shcherbatko1999VoltagedependentSC, title={Voltage-dependent sodium channel function is regulated through membrane mechanics.}, author={A. D. Shcherbatko and Fumihito Ono and George Mandel and Paul Brehm}, journal={Biophysical journal}, year={1999}, volume={77 4}, pages={1945-59} }