Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K 8644: implications for channel gating.

@article{Kass1987VoltagedependentMO,
  title={Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K 8644: implications for channel gating.},
  author={Robert S. Kass},
  journal={Circulation research},
  year={1987},
  volume={61 4 Pt 2},
  pages={I1-5}
}
This study investigated the voltage-dependent actions of the stereoisomers of the 1,4-dihydropyridine Bay K 8644 on calcium channel currents in heart cells. Whole-cell currents were recorded from enzymatically dispersed ventricular myocytes using the patch-clamp technique. Both enantiomers of this compound modulate calcium channel current in a voltage-dependent manner. The most prominent effect of (+)-Bay K 8644 is an inhibition of calcium channel current, which is more pronounced when currents… CONTINUE READING

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