Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits.

@article{Ikeda1996VoltagedependentMO,
  title={Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits.},
  author={Stephen R Ikeda},
  journal={Nature},
  year={1996},
  volume={380 6571},
  pages={
          255-8
        }
}
The most commonly used signal transduction pathway for receptor-mediated N-type Ca2+-channel modulation involves activation of a heterotrimeric G protein to produce voltage-dependent inhibition. Although it is widely assumed that Galpha mediates this effect, experiments to address this hypothesis directly are lacking. Here I show that transient overexpression of Gbetagamma in sympathetic neurons mimics and occludes the voltage-dependent Ca2+ channel modulation produced by noradrenaline (NA… CONTINUE READING

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