Voltage-dependent kinetics of an anionic channel of large unit conductance in macrophages and myotube membranes

@article{Schwarze1984VoltagedependentKO,
  title={Voltage-dependent kinetics of an anionic channel of large unit conductance in macrophages and myotube membranes},
  author={W. Schwarze and H. -A. Kolb},
  journal={Pfl{\"u}gers Archiv},
  year={1984},
  volume={402},
  pages={281-291}
}
Using the patch-clamp technique single-channel parameters and kinetic properties of an anionic channel are studied in cell-attached and exised membrane patches from peritonal macrophages of mouse and cultured chicken myotubes. The channel has a unit conductance of about 340 pS with a Q10 of 1.3. In addition a subconductance state of about 210 pS in frequently adopted. The selectivity ratio of PCl/PNa is about 5. In excised membrane patches the activation of the channel appears to be independent… CONTINUE READING

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