Voltage-dependent inhibition of the sodium pump by external sodium: Species differences and possible role of the N-terminus of the α-subunit

@article{Vasilets1993VoltagedependentIO,
  title={Voltage-dependent inhibition of the sodium pump by external sodium: Species differences and possible role of the N-terminus of the α-subunit},
  author={Larisa A. Vasilets and Toshiko Ohta and Shunsuke Noguchi and Masaru Kawamura and Wolfgang Schwarz},
  journal={European Biophysics Journal},
  year={1993},
  volume={21},
  pages={433-443}
}
Currents generated by the Na+/K+ ATPase were measured under voltage clamp in oocytes of Xenopus laevis. The dependence of pump current on external [Na+] was investigated for the endogenous Xenopus pump as well as for wild-type and mutated pumps of electroplax of Torpedo californica expressed in the oocytes. The mutants had α-subunits truncated before position Lys28 (αΔK28) or Thr29 (αΔT29) of the N-terminus. The currents generated by all variants of pump molecules in the presence of 5 mM K… CONTINUE READING