Voltage-dependent conformational changes in connexin channels.

  title={Voltage-dependent conformational changes in connexin channels.},
  author={Thaddeus A. Bargiello and Qingxiu Tang and Seunghoon Oh and Taekyung Kwon},
  journal={Biochimica et biophysica acta},
  volume={1818 8},
Channels formed by connexins display two distinct types of voltage-dependent gating, termed V(j)- or fast-gating and loop- or slow-gating. Recent studies, using metal bridge formation and chemical cross-linking have identified a region within the channel pore that contributes to the formation of the loop-gate permeability barrier. The conformational changes are remarkably large, reducing the channel pore diameter from 15 to 20Å to less than 4Å. Surprisingly, the largest conformational change… CONTINUE READING

From This Paper

Topics from this paper.
15 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…