Voltage-dependent calcium influx in human sperm assessed by simultaneous optical detection of intracellular calcium and membrane potential.

@article{LinaresHernndez1998VoltagedependentCI,
  title={Voltage-dependent calcium influx in human sperm assessed by simultaneous optical detection of intracellular calcium and membrane potential.},
  author={L Linares-Hern{\'a}ndez and Alberto Mart{\'i}n Guzm{\'a}n-Grenfell and Juan Jos{\'e} Hicks-G{\'o}mez and Marco T. Gonzalez-Martinez},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1372 1},
  pages={1-12}
}
There are several physiological and pharmacological evidences indicating that opening of voltage dependent calcium channels play a crucial role in the induction of the acrosome reaction in mammalian sperm. In mature sperm, physiological inductors of the acrosome reaction such as ZP3, a zona pellucida protein, and the steroid hormone progesterone, induce depolarization and calcium influx, which are required for the acrosome reaction. In this paper, we describe a voltage-dependent calcium influx… CONTINUE READING

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