Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).

@article{Bezprozvanny1995VoltagedependentBO,
  title={Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).},
  author={Ilya B Bezprozvanny and Richard W. Tsien},
  journal={Molecular pharmacology},
  year={1995},
  volume={48 3},
  pages={540-9}
}
Four different types of Ca2+ channel alpha 1 subunits, representing the major classes of voltage-gated Ca2+ channels, were individually coexpressed along with alpha 2/delta and beta 2b subunits in Xenopus oocytes. These subunits (and the encoded channel types and major tissues of origin) included alpha 1C (L-type, cardiac), alpha 1B (N-type, central nervous system), alpha 1A (P/Q-type, central nervous system), and alpha 1E (most likely R-type, central nervous system). Divalent cation currents… CONTINUE READING
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