• Chemistry, Medicine
  • Published in Molecular pharmacology 1979

Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques.

@article{Koblin1979VoltagedependentAV,
  title={Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques.},
  author={Donald D. Koblin and Henry A. Lester},
  journal={Molecular pharmacology},
  year={1979},
  volume={15 3},
  pages={
          559-80
        }
}
This study employs voltage-clamp techniques to survey the action of several local anesthetics on the nicotinic acetylcholine receptor of Electrophorus electroplaques. These drugs partially block the steady-state activation of receptors during bath application of agonist. Certain anesthetics alter the kinetics of voltage-jump relaxations during such application and alter the waveform of neurally-evoked postsynaptic currents. Procaine, tetracaine, and QX-222 act similarly at concentrations of 25… CONTINUE READING