Voltage-dependent Gating of Single Wild-Type and S4 Mutant KAT1 Inward Rectifier Potassium Channels

@article{Zei1998VoltagedependentGO,
  title={Voltage-dependent Gating of Single Wild-Type and S4 Mutant KAT1 Inward Rectifier Potassium Channels },
  author={Paul C. Zei and Richard W. Aldrich},
  journal={The Journal of General Physiology},
  year={1998},
  volume={112},
  pages={679 - 713}
}
The voltage-dependent gating mechanism of KAT1 inward rectifier potassium channels was studied using single channel current recordings from Xenopus oocytes injected with KAT1 mRNA. The inward rectification properties of KAT1 result from an intrinsic gating mechanism in the KAT1 channel protein, not from pore block by an extrinsic cation species. KAT1 channels activate with hyperpolarizing potentials from -110 through -190 mV with a slow voltage-dependent time course. Transitions before first… CONTINUE READING

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