Voltage dependencies of the effects of chlorpromazine on the nicotinic receptor channel from mouse muscle cell line So18.

Abstract

The effects of chlorpromazine (CPZ) on nicotinic acetylcholine receptor (nAChR) were re-investigated by patch-clamp recordings on a mouse muscle cell line: (1) CPZ decreased the channel-opening frequency and, thus, acted as a closed-channel blocker. This effect was independent of the membrane potential and was consistent with an enhanced desensitization of… (More)

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