Voltage dependence of the rheogenic Na+/K+ ATPase in the membrane of oocytes ofXenopus laevis

@article{Lafaire1986VoltageDO,
  title={Voltage dependence of the rheogenic Na+/K+ ATPase in the membrane of oocytes ofXenopus laevis},
  author={A. V. Lafaire and Wolfgang Schwarz},
  journal={The Journal of Membrane Biology},
  year={1986},
  volume={91},
  pages={43-51}
}
Electrophysiological experiments were performed to analyze the Na+/K+-ATPase in full-grown prophase-arrested oocytes ofXenopus laevis. If the Na+/K+-ATPase is inhibited by dihydroouabain (DHO), the resting potential of the membrane of Na+-loaded oocytes may depolarize by nearly 50 mV. This hyperpolarizing contribution to the resting potential depends on the degree of activation of the Na+/K+-ATPase and varies with intra-cellular Na+ activity (a Na i ), and extracellular K+ (K 0 + ) It is… CONTINUE READING