Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics

  title={Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics},
  author={CE Jahr and Cf Stevens},
  booktitle={Journal of Neuroscience},
The conductance activated in many mammalian CNS neurons by the glutamate analog NMDA is inhibited at hyperpolarized potentials by extracellular magnesium. Whole-cell recordings from hippocampal neurons in culture were used to determine the voltage dependence of the NMDA conductance in the presence of extracellular magnesium concentrations from 1 microM to 10 mM. The conductance-voltage data are well fitted by a gating function derived from rate constants determined in an earlier study of the… 

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