Voltage clamp methods for the study of membrane currents and SR Ca(2+) release in adult skeletal muscle fibres.

@article{HernndezOchoa2012VoltageCM,
  title={Voltage clamp methods for the study of membrane currents and SR Ca(2+) release in adult skeletal muscle fibres.},
  author={Erick O Hern{\'a}ndez-Ochoa and Martin F. Schneider},
  journal={Progress in biophysics and molecular biology},
  year={2012},
  volume={108 3},
  pages={98-118}
}
Skeletal muscle excitation-contraction (E-C)(1) coupling is a process composed of multiple sequential stages, by which an action potential triggers sarcoplasmic reticulum (SR)(2) Ca(2+) release and subsequent contractile activation. The various steps in the E-C coupling process in skeletal muscle can be studied using different techniques. The simultaneous recordings of sarcolemmal electrical signals and the accompanying elevation in myoplasmic Ca(2+), due to depolarization-initiated SR Ca(2… CONTINUE READING

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