Voltage-activated sodium conductances in cultured normal and trisomy 16 dorsal root ganglion neurons from the fetal mouse.

@article{Orozco1988VoltageactivatedSC,
  title={Voltage-activated sodium conductances in cultured normal and trisomy 16 dorsal root ganglion neurons from the fetal mouse.},
  author={C B Orozco and Charles J. Epstein and Stanley I. Rapoport},
  journal={Brain research},
  year={1988},
  volume={466 2},
  pages={265-74}
}
Current and voltage clamp recordings were made with a patch-clamp technique from large, light, dorsal root ganglia (DRG) neurons in tissue culture, derived from trisomy 16 and normal fetal mice. In a Na gradient of [52 mM]o/[28 mM]i, the action potential was accelerated, depolarization and repolarization were faster and the total Na conductance was higher in trisomic neurons. A tetrodotoxin (TTX)-sensitive, fast Na current was demonstrated, about 0.9 nA in trisomic and 0.3 nA in control neurons… CONTINUE READING