Voltage-Induced Misfolding of Zinc-Replete ALS Mutant Superoxide Dismutase-1.

Abstract

The monomerization of Cu, Zn superoxide dismutase (SOD1) is an early step along pathways of misfolding linked to amyotrophic lateral sclerosis (ALS). Monomerization requires the reversal of two post-translational modifications that are thermodynamically favorable: (i) dissociation of active-site metal ions and (ii) reduction of intramolecular disulfide… (More)
DOI: 10.1021/acschemneuro.5b00146

6 Figures and Tables

Topics

  • Presentations referencing similar topics