Voltage-Gated Potassium Channels: Regulation by Accessory Subunits

@article{Li2006VoltageGatedPC,
  title={Voltage-Gated Potassium Channels: Regulation by Accessory Subunits},
  author={Yan Li and Sung Yon Um and Thomas V. McDonald},
  journal={The Neuroscientist},
  year={2006},
  volume={12},
  pages={199 - 210}
}
Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons and other cell types. A precise control of neuronal action potential patterns underlies the basic functioning of the central and peripheral nervous system. This control relies on the adaptability of potassium channel activities. The functional diversity of potassium currents, however, far exceeds the considerable molecular diversity of this class of genes. Potassium current diversity contributes to the… 

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References

SHOWING 1-10 OF 153 REFERENCES
Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
TLDR
A β-subunit (Kvβ1) is cloned that is specifically expressed in the rat nervous system and confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro.
Modulation of A-type potassium channels by a family of calcium sensors
TLDR
Three Kv channel-interacting proteins (KChIPs) that bind to the cytoplasmic amino termini of Kv4 α-subunits are described that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs).
TLDR
The capacity of MiRPs to partner with multiple alpha-subunits in experimental cells appears to reflect still undiscovered roles for the KCNE-encoded peptides in vivo, and is considered in health disease and future research directions.
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel
TLDR
Electrostatic properties of the side portals and positions of the T1 domain and β sub unit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the β subunit.
Structure of a voltage-dependent K+ channel beta subunit.
TLDR
The structure of the conserved core of mammalian beta subunits is determined by X-ray crystallography at 2.8 A resolution and suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell.
KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.
TLDR
It is confirmed that all KChIPs 1-4 are integral components of native A-type Kv channel complexes and are likely to play a major role as modulators of somatodendritic excitability.
Cloning and Expression of a Novel K+ Channel Regulatory Protein, KChAP*
TLDR
The cloning of a novel gene encoding a Kv channel binding protein (KChAP, forK + channel-associatedprotein), which modulates the expression of Kv2 channels in heterologous expression system assays is reported, suggesting that KChAP may act as a novel type of chaperone protein to facilitate the cell surface expression of KT channels.
KChIPs and Kv4 α Subunits as Integral Components of A-Type Potassium Channels in Mammalian Brain
TLDR
It is confirmed that all KChIPs 1-4 are integral components of native A-type Kv channel complexes and are likely to play a major role as modulators of somatodendritic excitability.
...
...