Voltage-Dependent Formation of Stable, Ion Conductive Pores in Suspended Lipid Bilayers from Oxidized Lipids

@inproceedings{Schroder2017VoltageDependentFO,
  title={Voltage-Dependent Formation of Stable, Ion Conductive Pores in Suspended Lipid Bilayers from Oxidized Lipids},
  author={Andr{\'e} Pierre Schroder and Ekaterina Zaitseva and Carlos Manuel Marques and Jan C. Behrends},
  year={2017}
}
Oxidation of membrane lipids is a ubiquitous phenomenon in eukaryotic cells occurring as a consequence of the generation of reactive oxygen species by mitochondrial or peroxisomal activity and irradiation with photons or ions. Lipid hydroperoxidation, the primary step of the oxidative reactions, has been shown to induce molecular area increase, enhanced fluctuations and tube formation in giant unilamellar vesicles. Surprisingly, however, despite a 75% loss of elastic modulus, even fully… CONTINUE READING