Voltage Dependence of Open Channel Blockade: Onset and Offset Rates

@article{Tikhonov1998VoltageDO,
  title={Voltage Dependence of Open Channel Blockade: Onset and Offset Rates},
  author={Denis B. Tikhonov and Lev G Magazanik},
  journal={The Journal of Membrane Biology},
  year={1998},
  volume={161},
  pages={1-8}
}
It is well known that open ion channels can bind different drugs at the pore, and this kind of interaction impedes the ion flux through the channel. In many cases, the block is dependent on the transmembrane potential difference. This article discusses the practical application and limits of models used for describing such block. Any voltage dependence of block must be due to the movement of some charge(s) in the membrane electrical field. Since prominent voltage dependence has been found for… CONTINUE READING