Voltage‐gated calcium channels play crucial roles in the glutamate‐induced phase shifts of the rat suprachiasmatic circadian clock
@article{Kim2005VoltagegatedCC, title={Voltage‐gated calcium channels play crucial roles in the glutamate‐induced phase shifts of the rat suprachiasmatic circadian clock}, author={Do Young Kim and Hee Joo Choi and Jeong Sook Kim and Yoon-Sik Kim and Do Ung Jeong and Hyung-Cheul Shin and Mi Jin Kim and Hee Chul Han and Seung Kil Hong and Yang In Kim}, journal={European Journal of Neuroscience}, year={2005}, volume={21} }
The resetting of the circadian clock based on photic cues delivered by the glutamatergic retinohypothalamic tract is an important process helping mammals to function adaptively to the daily light–dark cycle. To see if the photic resetting relies on voltage‐gated Ca2+ channels (VGCCs), we examined the effects of VGCC blockers on the glutamate‐induced phase shifts of circadian firing activity rhythms of suprachiasmatic nucleus (SCN) neurons in hypothalamic slices. First, we found that a cocktail…
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References
SHOWING 1-10 OF 34 REFERENCES
The role of glutamate in the photic regulation of the suprachiasmatic nucleus
- BiologyProgress in Neurobiology
- 1996
Pituitary adenylyl cyclase-activating peptide: a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1999
The results reveal that PACAP is a significant component of the Glu-mediated light-entrainment pathway and may encode the amplitude of adaptive circadian behavioral responses to the natural range of intensities of nocturnal light.
Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO.
- BiologyScience
- 1994
Data indicate that Glu release, NMDA receptor activation, NOS stimulation, and NO production link light activation of the retina to cellular changes within the SCN mediating the phase resetting of the biological clock.
A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock
- BiologyNature
- 1998
These findings implicate the release of intracellular Ca2+ through ryanodine receptors in the light-induced phase delay of the circadian clock restricted to the early night.
The role of inositol trisphosphate-induced Ca2+ release from IP3-receptor in the rat suprachiasmatic nucleus on circadian entrainment mechanism
- BiologyNeuroscience Letters
- 1999
cGMP-dependent protein kinase inhibitors block light-induced phase advances of circadian rhythms in vivo.
- BiologyThe American journal of physiology
- 1996
The results suggest that PKG activity is necessary, but not sufficient, for normal photic responsiveness and that PKA activity is not required, and supports the notion that photic entrainment is influenced by biochemical pathways that differentially regulate sensitivity in a phase-dependent manner.
NMDA as Well as Non-NMDA Receptor Antagonists Can Prevent the Phase-Shifting Effects of Light on the Circadian System of the Golden Hamster
- BiologyJournal of biological rhythms
- 1992
The present experiments provide further evidence that EAA receptors mediate the effects of light on the circadian system, and suggest that both NMDA and non-NMDA receptor types may be involved.
Calcium plays a central role in phase shifting the ocular circadian pacemaker of Aplysia
- BiologyJournal of Comparative Physiology A
- 2004
Low calcium treatments were found to cause phase shifts which resembled those produced by the transmitter serotonin, and these results are consistent with a model in which serotonin phase shifts the ocular pacemaker by decreasing a transmembrane calcium flux through membrane hyperpolarization while light-induced phase shifts are mediated by an increase in calcium flux.
cGMP-dependent protein kinase inhibitor blocks light-induced phase advances of circadian rhythms in vivo
- BiologyNeuroscience Letters
- 1995
Signaling in the suprachiasmatic nucleus: selectively responsive and integrative
- BiologyCell and Tissue Research
- 2002
Changing patterns of sensitivities demonstrate that the circadian clock controls multiple intracellular gates, which ensures that they can be opened selectively only at specific points in the circadian cycle.