Volcano Plots in Analyzing differential Expressions with mRNA microarrays

  title={Volcano Plots in Analyzing differential Expressions with mRNA microarrays},
  author={Wentian Li},
  journal={Journal of bioinformatics and computational biology},
  volume={10 6},
A volcano plot displays unstandardized signal (e.g. log-fold-change) against noise-adjusted/standardized signal (e.g. t-statistic or -log(10)(p-value) from the t-test). We review the basic and interactive use of the volcano plot and its crucial role in understanding the regularized t-statistic. The joint filtering gene selection criterion based on regularized statistics has a curved discriminant line in the volcano plot, as compared to the two perpendicular lines for the "double filtering… CONTINUE READING
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