Volatility of Mutator Phenotypes at Single Cell Resolution

  title={Volatility of Mutator Phenotypes at Single Cell Resolution},
  author={Scott R Kennedy and Eric M. Schultz and Thomas Mackey Chappell and Brendan F. Kohrn and Gary M. Knowels and Alan J. Herr},
  booktitle={PLoS genetics},
Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Historically, the measurement of mutation rates has relied on scoring the occurrence of rare mutations in target genes in large populations of cells. Averaging mutation rates over large cell populations assumes that new mutations arise at a constant rate during each cell division. If the mutation rate is not constant, an expanding mutator population may contain subclones with widely divergent rates of evolution… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 64 references

An information criterion (AIC)

  • H Akaike
  • Math Sci
  • 1976
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…