Volatile sulfur compounds as a predictor for esophagogastroduodenal mucosal injury.


BACKGROUND/AIMS Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions. Since halitosis is closely associated with volatile sulfur compounds (VSCs), we used a Halimeter and gas chromatography to measure VSCs in patients with Helicobacter-pylori (H. pylori)-associated gastric diseases. METHODS We categorized 72 patients with H. pylori infection into two groups based on their endoscopic findings: a non-erosive mucosal group (NE, n=24) and an erosive mucosal group (E, n=48). Halitosis was objectively assessed by applying either a Halimeter to breath air or gas chromatography to gastric juice. Simultaneously, the expression of VSC-generating enzyme was measured with reverse-transcriptase PCR using mRNA isolated from biopsy tissues. RESULTS The levels of VSCs in exhaled breaths or aspirated gastric juices differed significantly between the NE and E groups (p<0.00001), suggesting that VSCs might reflect eroded epithelial damage induced by H. pylori infection. The expressions of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) were broadly consistent with the degree of mucosal injury. CONCLUSIONS Erosive changes in esophagogastroduodenal mucosa were strongly correlated with increased VSC levels, suggesting that halitosis might result from H. pylori-associated erosive lesions.

DOI: 10.5009/gnl.2008.2.2.113

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@article{Yoo2008VolatileSC, title={Volatile sulfur compounds as a predictor for esophagogastroduodenal mucosal injury.}, author={Seung Hee Yoo and Hyeon Sik Jung and Wee Sik Sohn and Bong Hwan Kim and Bon Ho Ku and Young Saeng Kim and Sang Woon Park and Ki-Baik Hahm}, journal={Gut and liver}, year={2008}, volume={2 2}, pages={113-8} }