Volatile anaesthetic enhancement of paired-pulse depression investigated in the rat hippocampus in vitro.

@article{Pearce1996VolatileAE,
  title={Volatile anaesthetic enhancement of paired-pulse depression investigated in the rat hippocampus in vitro.},
  author={Robert A Pearce},
  journal={The Journal of physiology},
  year={1996},
  volume={492 ( Pt 3)},
  pages={823-40}
}
1. A prominent in vivo effect of general anaesthetics, including volatile anaesthetics such as halothane, is the prolonging of paired-pulse depression of the hippocampal CA1 population spike. The mechanisms by which volatile anaesthetics produce this effect were investigated in the hippocampal brain slice preparation by testing the effect of halothane on several long-lasting inhibitory processes, including the calcium-activated potassium current that underlies the slow after-hyperpolarization… CONTINUE READING