Vogt-Koyanagi-Harada Disease

@article{Damico2005VogtKoyanagiHaradaD,
  title={Vogt-Koyanagi-Harada Disease},
  author={Francisco Max Damico and Szilard Kiss and Lucy H Young},
  journal={Seminars in Ophthalmology},
  year={2005},
  volume={20},
  pages={183 - 190}
}
Vogt-Koyanagi-Harada disease (VKH) is a multisystem autoimmune disorder principally affecting pigmented tissues in the ocular, auditory, integumentary and central nervous systems. Patients are typically 20 to 50 years old and have no history of either surgical or accidental ocular trauma. Pigmented races are more commonly affected. Depending on revised diagnostic criteria, the disease is classified as complete, incomplete or probable based on the presence of extraocular findings (neurological… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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References

SHOWING 1-10 OF 60 REFERENCES
Vogt-Koyanagi-Harada disease.
  • R. Read
  • Medicine
    Ophthalmology clinics of North America
  • 2002
UVEOMENINGOENCEPHALITIC SYNDROME (VOGT-KOYANAGI-HARADA).
TLDR
In this report the clinical features of the syndrome will be surveyed, and two cases focusing on neurological aspects will be studied.
Tyrosinase Family Proteins Are Antigens Specific to Vogt-Koyanagi-Harada Disease1
TLDR
It is found that exposure of lymphocytes from patients with VKH disease to peptides (30-mer) derived from the tyrosinase family proteins led to significant proliferation of the lymphocytes.
Echographic features of the Vogt-Koyanagi-Harada syndrome.
TLDR
Standardized echography should be considered an important diagnostic tool in VKH syndrome, especially when visualization of the fundus is poor or when clinical presentation is atypical.
Immunohistochemical studies of Vogt-Koyanagi-Harada disease with sunset sky fundus.
TLDR
Evidence of T and B lymphocytes in these uveal tissues indicates that the inflammation remained active even at the convalescent stage of Vogt-Koyanagi-Harada disease.
Ocular and extraocular inflammation induced by immunization of tyrosinase related protein 1 and 2 in Lewis rats.
TLDR
Lewis rats developed an ocular and extraocular inflammatory disease 12 days after immunization with TRP1 or TRP2 that was characterized clinically by the infiltration of inflammatory cells and accumulation of massive fibrin in the anterior and posterior chambers of the eye.
Vogt-Koyanagi-Harada syndrome. Clinical course, therapy, and long-term visual outcome.
TLDR
The early, aggressive use of systemic corticosteroids in patients with Vogt-Koyanagi-Harada syndrome and a gradual tapering of drug dosage for 6 months after presentation are recommended.
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