Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase inhibitors from Tabernaemontana divaricata root.

@article{Ingkaninan2006VobasinylibogaBA,
  title={Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase inhibitors from Tabernaemontana divaricata root.},
  author={Kornkanok Ingkaninan and Kanokwan Changwijit and Khanit Suwanborirux},
  journal={The Journal of pharmacy and pharmacology},
  year={2006},
  volume={58 6},
  pages={847-52}
}
The roots of the Thai medicinal plant, Tabernaemontana divaricata (L.) R. Br. ex Roem. & Schult., were investigated for their content of acetylcholinesterase inhibitors. Bioassay-guided fractionation using the Ellman colorimetric method led to the isolation of two bisindole alkaloids, 19,20-dihydrotabernamine and 19,20-dihydroervahanine A. The compounds showed higher inhibitory activity on acetylcholinesterase in comparison with galanthamine, a well-known acetylcholinesterase inhibitor. The… CONTINUE READING

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