Vma22p Is a Novel Endoplasmic Reticulum-associated Protein Required for Assembly of the Yeast Vacuolar H+-ATPase Complex (*)

@article{Hill1995Vma22pIA,
  title={Vma22p Is a Novel Endoplasmic Reticulum-associated Protein Required for Assembly of the Yeast Vacuolar H+-ATPase Complex (*)},
  author={Kathryn J. Hill and Tom H. Stevens},
  journal={The Journal of Biological Chemistry},
  year={1995},
  volume={270},
  pages={22329 - 22336}
}
  • K. Hill, T. Stevens
  • Published 22 September 1995
  • Biology, Chemistry
  • The Journal of Biological Chemistry
The Saccharomyces cerevisiae vacuolar H-ATPase (V-ATPase) is a multi-subunit complex that can be structurally and functionally divided into peripheral (V) and integral membrane (V) sectors. The vma22-1 mutation was isolated in a screen for mutants defective in V-ATPase function. vma22Δ cells contain no V-ATPase activity due to a failure to assemble the enzyme complex; V subunits accumulate in the cytosol, and the V 100-kDa subunit is rapidly degraded. Turnover of the 100-kDa integral membrane… 

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TLDR
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