Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach

@inproceedings{Liaw2015VitroprocinesNA,
  title={Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach},
  author={C C Liaw and Pei-Chin Chen and C J Shih and S P Tseng and Ying-Mi Lai and Chi-Hsin Hsu and Pieter C. Dorrestein and Yu-liang Yang},
  booktitle={Scientific reports},
  year={2015}
}
A robust and convenient research strategy integrating state-of-the-art analytical techniques is needed to efficiently discover novel compounds from marine microbial resources. In this study, we identified a series of amino-polyketide derivatives, vitroprocines A-J, from the marine bacterium Vibrio sp. QWI-06 by an integrated approach using imaging mass spectroscopy and molecular networking, as well as conventional bioactivity-guided fractionation and isolation. The structure-activity… CONTINUE READING
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