Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells.

@article{Ciambrone1992VitronectinRT,
  title={Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells.},
  author={Giuseppe Ciambrone and Paula J. McKeown-Longo},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 19},
  pages={13617-22}
}
The effect of extracellular matrix composition on the location, amount, and activity of cell-associated urokinase-type plasminogen activator was tested using HT-1080 cells adherent to either fibronectin or vitronectin. Specific immunoprecipitation of newly synthesized urokinase indicated that cells adherent to fibronectin synthesized 2-3-fold more urokinase than cells adherent to vitronectin. Complexes of urokinase and plasminogen activator inhibitor type 1 (PAI-1) were detected in cell layers… CONTINUE READING

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