Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells.

@article{Gil2009VitronectinPO,
  title={Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells.},
  author={Joaqu{\'i}n Guillermo Ram{\'i}rez Gil and Dr. Savio L-Y. Woo and Joong-Hyun Shim and Sung-Eun Kim and Huabei You and Sung-Hye Park and Sun Ha Paek and Sungshin Kim and Jonghoon Kim},
  journal={FEBS letters},
  year={2009},
  volume={583 3},
  pages={
          561-7
        }
}
We demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that… CONTINUE READING
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