Vitiligo

@article{Ezzedine2015Vitiligo,
  title={Vitiligo},
  author={Khaled Ezzedine and Viktoria Eleftheriadou and Maxine E Whitton and Nanja van Geel},
  journal={The Lancet},
  year={2015},
  volume={386},
  pages={74-84},
  url={https://api.semanticscholar.org/CorpusID:208791128}
}
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ghr.nlm.nih.gov
233 Citations
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233 Citations

Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions.

Vitiligo: A Narrative Review

The preceding study aims to provide insight into the potential prospects of vitiligo medication while also summarizing the current body of knowledge on the condition.

Vitiligo, from Pathogenesis to Therapeutic Advances: State of the Art

A convergence theory was proposed that combines all existing theories into a comprehensive one in which several mechanisms contribute to the reduction of melanocyte viability, and the pathogenesis of vitiligo was analyzed.

Management of Stable Vitiligo—A Review of the Surgical Approach

It is concluded that the extent of repigmentation, regardless of the treatment method, is greatest in stable localized vitiligo patients, and cellular methods are the best therapeutic option for large-sized lesions.

Vitiligo and the Role of Newer Therapeutic Modalities

This review is a summary of various theories of the pathogenesis of vitiligo as well as an overview of the therapeutic modalities that are currently available for the same.

Comorbidities in vitiligo: comprehensive review

The association with the most frequent comorbidities associated with vitiligo, a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis, is reviewed.

Vitiligo and Skin of Color

According to the psychological and social impact, even the management should be planned and discussed considering combinatory therapies as well as depigmenting approaches not frequently asked by fair-skin patients.

Response of localized, resistant, tingling vitiligo to pregabalin: A case report

A case of 26‐year‐old female patient, whose vitiligo patches were associated with unusual crawling and tingling sensation and responded to a clinical trial of pregabalin is reported.

Labial vitiligo associated with a factice disorder: a case report

Oral mucosa vitiligo must be known by oral surgeon who has to master the diagnosis and treatments in association with dermatologist, given the concomitant skin involvement that is almost mandatory.

Widespread Depigmented and Hypopigmented Patches

Female patients with longer duration of disease and patients with extensive involvement are more likely to develop autoimmune thyroid disease and anti-nuclear antibody positivity is seen more frequently in female patients and in early-onset disease.
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12 References

Vitiligo update.

The genetics of generalized vitiligo

It is anticipated that the discovery of biological pathways of Vitiligo pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to the treatment and prevention of vitiligo and its associated autoimmune diseases.

Recent progress in the genetics of generalized vitiligo.

Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff

There is a body of interlocking, compelling evidence supporting an autoimmune basis for most or all cases of generalized vitiligo.

Innate immune mechanisms in vitiligo: danger from within.

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

BACKGROUND Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other…

PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.

The results implicate PTPN22 in mediating susceptibility to generalized vitiligo and associated autoimmune diseases, but do not support a role for CTLA4.

Common variants in FOXP1 are associated with generalized vitiligo

Testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 and 6q27 encompassing CCR6.

Fine-mapping of vitiligo susceptibility loci on chromosomes 7 and 9 and interactions with NLRP1 (NALP1).

Fine-scale genetic association analyses in two independent series of Caucasian multiplex families support the validity of the chromosomes 7 and 9 linkage/association signals and underscore the utility of gene-gene interaction analysis in characterizing the genetic effects of candidate association signals.

Multiple genes and locus interactions in susceptibility to vitiligo.

Investigation of the genetic interaction among these loci (and with a previously identified susceptibility gene, NLRP1, on chromosome 17) as risk factors for vitiligo demonstrates the complex nature of this disease.