• Corpus ID: 8136355

Vitaxin applied molecular evolution.

  title={Vitaxin applied molecular evolution.},
  author={Katalin Mikecz},
  journal={Current opinion in investigational drugs},
  volume={1 2},
  • K. Mikecz
  • Published 1 October 2000
  • Medicine
  • Current opinion in investigational drugs
Vitaxin is a humanized version of LM-609 (an mAb licensed from the Scripps Research Institute and Dr David Cheresh in May 1994, which blocks the integrin receptor, alpha v beta 3) [172038]. It is in phase II trials for the potential treatment of leiomyosarcoma [316471] and is also being studied in phase I trials as an anti-inflammatory and potential rheumatoid arthritis therapy [364031,313665]. Vitaxin and non-peptides are under evaluation for use in the treatment of other diseases in which… 

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