Isoniazid (I.N.H.) in the treatment of depressive syndrome: a pilot trial.
- V G Joshi
- Diseases of the nervous system
The evidence for a biochemical basis of schizophrenia appears to be strong at present. To quote Boyd, 1970, "there can be little doubt that such an apparently purely functional mental disease as schizophrenia, with its distressing delusions and hallucinations and split personality, has a biochemical lesion as its basis." Despite this, the overall attempts to elucidate the exact nature of the underlying biochemical lesion, have not met with much success so far. The possible role of vitamins in the etiology and therapy of schizophrenia too has been reviewed from time to time but only with conflicting results. (Hawkins, D. and Pauling, L, 1973; Walter Wolman, 1976). Deficiencies of vitamins have been demonstrated mainly in chronic schizophrenics and this has been said to result from their poor dietary intake. As similar deficiencies are not usually encountered in acute schizophrenics with a short duration of illness, vitamins were not considered important in the aetiology of the illness. However, some authorities still maintain that vitamin deficiencies may play an