Vitamine–B12–deficiency causing isolated and partially reversible leukoencephalopathy

  title={Vitamine–B12–deficiency causing isolated and partially reversible leukoencephalopathy},
  author={M.-S. Vry and Katharina Haerter and Oliver Kastrup and E. Gizewski and Markus Frings and Matthias Maschke},
  journal={Journal of Neurology},
Sirs: The hallmarks of vitamine B12 (cobalamine) deficiency as a neurological disease are subacute combined degeneration of the spinal cord in combination with spinocerebellar tract and brain pyramidal lesions, peripheral neuropathy, optic nerve disease, and psychiatric symptoms [1, 2]. The association between cobalamine deficiency and diseases of the nervous system has been reported since the 1950s. Already in 1884, Leichtenstein assumed an association between pernicious anaemia and spinal… CONTINUE READING