Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells.

@article{Yokoyama2008VitaminKI,
  title={Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells.},
  author={Tomohisa Yokoyama and Keisuke Miyazawa and Munekazu Naito and Juri Toyotake and Testuzo Tauchi and Masahiro Itoh and Akira Yuo and Yuho Hayashi and M J Georgescu and Yasuko Kondo and Seiji Kondo and Kazuma Ohyashiki},
  journal={Autophagy},
  year={2008},
  volume={4 5},
  pages={629-40}
}
Vitamin K2 (menaquinone-4: VK2) is a potent inducer for apoptosis in leukemia cells in vitro. HL-60bcl-2 cells, which are derived from a stable transfectant clone of the human bcl-2 gene into the HL-60 leukemia cell line, show 5-fold greater expression of the Bcl-2 protein compared with HL-60neo cells, a control clone transfected with vector alone. VK2 induces apoptosis in HL-60neo cells, whereas HL-60bcl-2 cells are resistant to apoptosis induction by VK2 but show inhibition of cell growth… CONTINUE READING

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