Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid

@article{Yaguchi1997VitaminKA,
  title={Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid},
  author={Makoto Yaguchi and Keisuke Miyazawa and Takamasa Katagiri and Jiroh Nishimaki and Masahiro Kizaki and Kaoru Tohyama and Keisuke Toyama},
  journal={Leukemia},
  year={1997},
  volume={11},
  pages={779-787}
}
Geranylgeraniol, a polyprenylalcohol composing the side chain of vitamin K2 (VK2), was previously reported to be a potent inducer of apoptosis in tumor cell lines (Ohzumi H et al, J Biochem 1995; 117: 11–13). We examined the apoptosis-inducing ability of VK2 (menaquinone 3 (MK3), MK4 and MK5) and its derivatives such as phytonadione (VK1), as well as polyprenylalcohols with side chains of various lengths including farnesol (C15-OH; FO), geranylgeraniol (C20-OH; GGO), and geranylfarnesol (C25-OH… CONTINUE READING

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