Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis.

@article{Ebina2013VitaminKA,
  title={Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis.},
  author={Kosuke Ebina and Kenrin Shi and Makoto Hirao and Shoichi Kaneshiro and Tokimitsu Morimoto and Kota Koizumi and Hideki Yoshikawa and Jun Hashimoto},
  journal={Modern rheumatology},
  year={2013},
  volume={23 5},
  pages={1001-7}
}
OBJECTIVES Vitamin K2 (VitK2) is reported to induce not only bone mineralization of human osteoblasts and apoptosis of osteoclasts, but also apoptosis of rheumatoid arthritis (RA) synovial cells, while its clinical effect on disease activity of RA remains unknown. METHODS 158 female RA patients (mean age 62.5 years) who had not been treated with warfarin, biologics, or teriparatide were enrolled in this study. VitK2 (45 mg/day) was administered in 70 patients with a serum undercarboxylated… CONTINUE READING