Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

@article{Vos2012VitaminKI,
  title={Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency},
  author={Melissa Vos and Giovanni Esposito and Janaka N. Edirisinghe and Sven Vilain and Dominik M Haddad and Jan R. Slabbaert and Stefanie Van Meensel and Onno Schaap and Bart de Strooper and Rangaswamy Meganathan and Vanessa Alexandra Morais and Patrik Verstreken},
  journal={Science},
  year={2012},
  volume={336},
  pages={1306 - 1310}
}
Keeping Mitochondria in the Pink Pink1 is a mitochondrial kinase, and loss of Pink1 function in flies and mice results in the accumulation of inefficient mitochondria. In a screen for modifiers of the Parkinson-associated gene, pink1, Vos et al. (p. 1306, published online 10 May; see the Perspective by Bhalerao and Clandinin) identified the fruit fly homolog of UBIAD1, “Heix.” UBIAD1 was localized in mitochondria and was able to convert vitamin K1 into vitamin K2/menaquinone (MK-n, n the number… 

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References

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
It is suggested that loss of Parkin function up-regulates the JNK signaling pathway, which may contribute to the vulnerability of dopaminergic neurons in Drosophila parkin mutants and perhaps autosomal recessive juvenile parkinsonism patients.
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