Vitamin K supplementation to decrease variability of International Normalized Ratio in patients on vitamin K antagonists: a literature review.

@article{Ford2008VitaminKS,
  title={Vitamin K supplementation to decrease variability of International Normalized Ratio in patients on vitamin K antagonists: a literature review.},
  author={Sarah K. Ford and Stephan Moll},
  journal={Current opinion in hematology},
  year={2008},
  volume={15 5},
  pages={504-8}
}
PURPOSE OF REVIEW Many patients treated with vitamin K antagonists have unstable International Normalized Ratios (INRs), increasing the risk of thrombosis and bleeding events. Changes in dietary vitamin K intake are known to lead to INR variability. Therefore, it has been hypothesized that providing stable intake of vitamin K through daily supplementation may lead to decreased INR variability. RECENT FINDINGS Four studies - one retrospective and three prospective - have examined the effects… CONTINUE READING