Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4.

@article{Thijssen1996VitaminKS,
  title={Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4.},
  author={Henk H W Thijssen and M J Drittij-Reijnders},
  journal={The British journal of nutrition},
  year={1996},
  volume={75 1},
  pages={121-7}
}
We measured the vitamin K status in postmortem human tissues (brain, heart, kidney, liver, lung, pancreas) to see if there is a tissue-specific distribution pattern. Phylloquinone (K1) was recovered in all tissues with relatively high levels in liver, heart and pancreas (medians, 10.6 (4.8), 9.3 (4.2), 28.4 (12.8) pmol(ng)/g wet weight tissue); low levels (< 2 pmol/g) were found in brain, kidney and lung. Menaquinone-4 (MK-4) was recovered from most of the tissues; its levels exceeded the K1… CONTINUE READING